Scientific Research Services

We conduct basic research, industrial research, and experimental development in the areas of:

• Chemical Sciences
• Biomedical Engineering
• Biological Sciences

We deliver expert-level capabilities in a broad spectrum of technologies and methodologies:

Synthetic and Molecular Engineering

• Synthesis of nitrogenous base derivatives, nucleosides, nucleotides
• Biopolymer conjugates (e.g., DNA-peptide, DNA-polymer, lipid-PEG conjugates)
• Supramolecular chemistry and self-assembly systems
• Liposome and micelle formation, MOF-based hybrid systems

Nanoparticle Synthesis & Biofunctionalization

• Wet-chemical and solvothermal synthesis of inorganic nanoparticles (e.g., Fe₃O₄, AuNPs, SiNPs)
• Polymer nanoparticles and lipid-based nanocarriers (LNPs, SLNs)
• Surface functionalization with ligands, peptides, antibodies, and fluorophores
• Click chemistry (CuAAC, SPAAC), PEGylation, EDC/NHS, biotin-streptavidin systems
• Targeted delivery systems and biosensing platforms

Biotechnology & Molecular Biology

• Recombinant DNA technology, expression of tagged and engineered proteins
• Molecular diagnostics: PCR, qPCR, ddPCR, LAMP
• Genetic editing: CRISPR-Cas systems
• Synthetic biology circuits, regulatory element design

Cellular and Biochemical Assays

• 2D/3D cell culture models, organoids, spheroids
• Co-culture and barrier models (e.g., BBB, gut-on-chip)
• Enzymatic pathway monitoring, redox balance, mitochondrial profiling
• DNA damage and repair assays (γH2AX, comet assay)
• Radiolabeling, phototoxicity, ROS and RNS quantification

Analytical & Spectroscopic Techniques

• Chromatography & Mass Spectrometry: HPLC, FPLC, UPLC, µLC, nanoLC, HR LC-MS/MS, MALDI-TOF/TOF, GC-MS, ZenoTOF, timsTOF, MSI
• Spectroscopy: UV-VIS, CD, FTIR, SPR, Raman, chemiluminescence, fluorescence (FRET, FLIM), SEM, TEM
• Structural & Thermal Analysis: NMR (1D/2D), DSC, TGA, MST, nanoDSF, ITC

Mass Spectrometry Imaging (MSI)

• MALDI-MSI for spatially resolved lipidomics, metabolomics, and proteomics
• DESI and SIMS-based tissue imaging
• Co-registration with histological and immunofluorescence data
• Imaging of drug distribution, tumor heterogeneity, and nanoparticle localization

Microscopy & Cytometry

• Optical, confocal, and super-resolution microscopy
• Flow cytometry (FACS, spectral, MACS), cell sorting
• Live-cell imaging, fluorescent biosensors, tracking assays

In Vivo Imaging & Animal Models

• Preclinical imaging: PET-CT, µCT, MRI, IVIS
• In vivo biosensors, fiber-optic probe implantation, catheter-based delivery
• Static/dynamic imaging, pharmacokinetics and biodistribution
• Small animal microsurgery (ischemia, tumors, xenografts, sensor implantation)

Computational Tools & Simulations

• Programming: Java, Kotlin, JavaScript Python, LaTeX, C++, Bash
• MD Simulations: GROMACS, AMBER, NAMD; free energy (FEP, metadynamics)
• Quantum Chemistry: Gaussian, ORCA, cp2k; DFT, TD-DFT, radical/photoreaction modeling
• QM/MM Hybrid Modeling: Reaction path prediction, enzyme catalysis in solution
• Visualization & Docking: AutoDock, VMD, Chimera, Avogadro, X3DNA

Why Collaborate With Us?